******** References ********

1. Research Projects

A. Neural mechanisms of working memory
B. Functiuons of the dorsolateral prefrontal cortex
C. Analysis of dynamic neural circuitry related to thinking and reasoning
D. Neurophysiological studies of meta-memory
E. Neural mechanisms of decision-making and its relation to the prefrontal functions
F. Neural correlate of top-down signal in the prefrontal cortex
G. Neural mechanisms for controlling emotion and understanding emotion

2. Publications

Funahashi, S. (2016) Physical features of visual images affect macaque monkey's preference for these images. Frontiers in Behavioral Neuroscience, fnbeh. 2016-00212. DOI:10.3389/fnbeh.2016.00212.

Mochizuki, K. and Funahashi, S. (2016) Response inhibition, prefrontal cortex, and their relation to the attention deficit/hyperactivity disorder. In: "Cognitive and Behavioral Phenotypes: New Trends for Research, Classification and diagnosis in Neuropsychology and Psychiatry," S.L. Santangelo and V. Jagaroo (eds.), Springer (in press)

Mochizuki, Y., Onaga, T., Shimazaki, H., Shimokawa, T., Tsubo Y., ...., Funahashi, S., .... and Shinomoto, S. (2016) Similarity in neuronal firing regimes across mammalian species. Journal of Neuroscience 36 (21): 5736-5747. DOI: 10.1523/JNEUROSCI.0230-16.2016.

Ichihara-Takeda, S., Takeda, K., Ikeda, N., Matsuyama, K., and Funahashi, S. (2016) Neuropsychological assessment of a new computerized cognitive task that was developed to train several cognitive functions simultaneously. Frontiers in Psychology, 7: 497. DOI:10.3389/fpsyg.2016.00497.

Mochizuki, K. and Funahashi, S. (2016) Prefrontal spatial working memory network predicts decision-making in a free choice saccade task. Journal of Neurophysiology 115: 127-142. DOI: 10.1152/jn.00255.2015.

Funahashi, S. (2015) Neural mechanism of dual-task interference. Kyoto University Research Activities, 5 (3): 22.

Funahashi, S. (2015) Developing a new model for working memory. Kyoto University Research Activities, 5 (3): 17.

Li, B.-M. and Funahashi, S. (2015) A step forward in the understanding of prefrontal cortical functions. Neuroscience Bulletine, 31: 161-163. DOI: 10.1007/s12264-015-1516-2.

Watanabe, K. and Funahashi, S. (2015) A dual-task paradigm for behavioral and neurobiological studies in nonhuman primates. Journal of Neuroscience Methods 246: 1-12. DOI: 10.1016/j.jneumeth.2015.03.006.

Funahashi, S. (2015) Functions of delay-period activity in the prefrontal cortex and mnemonic scotomas revisited. Frontiers in Systems Neuroscience, 9: 2 DOI:10.3389/fnsys.2015.00002.

Ichihara-Takeda, S., Yazawa, S., Murahara, T., Toyoshima, T., Shinozaki, J., Ishiguro, M., Shiraishi, H., Ikeda, N., Matsuyama, K., Funahashi, S., and Nagamine, T. (2015) Modulation of alpha activity in the parieto-occipital area by distractors during a visuospatial working memory task: a magnetoencephalographic study. Journal of Cognitive Neuroscience, 27: 453-463. DOI: 10.1162/jocn_a_00718.

Watanabe, K. and Funahashi, S. (2015) Primate model of interference control. Current Opinion in Behavioral Sciences 1: 9-16. DOI:10.1016/j.cobeha.2014.07.004

Funahashi, S. (2014) Saccade-related activity in the prefrontal cortex: its role in eye movement control and cognitive functions. Frontiers in Integrative Neuroscience 8: 54. DOI: 10.3389/fnint.2014.00054.

Mochizuki, K. and Funahashi, S. (2014) Opposing history effect of preceding decision and action in the free choice of saccade direction. Journal of Neurophysiology 112: 923-932. DOI: 10.1152/jn.00846.2013.

Watanabe, K. and Funahashi, S. (2014) Neural mechanisms of dual-task interference and cognitive capacity limitation in prefrontal cortex. Nature Neuroscience 17: 601-611. DOI: 10.1038/nn.3667

Funahashi, S. and Andreau, J.M. (2013) Prefrontal cortex and neural mechanisms of executive function. Journal of Physiology Paris 107: 471-482. DOI: 10.1016/j.jphysparis.2013.05.001.

Funahashi, S. (2013) Thalamic mediodorsal nucleus and its participation in spatial working memory processes: comparison with the prefrontal cortex. Frontier in Systems Neuroscience, 7: 36 doi: 10.3389/fnsys.2013.00036.

Funahashi, S. (2013) Space representation in the prefrontal cortex. Progresss in Neurobiology103: 131-155. DOI: 10.1016/j.pneurobio.2012.04.002.

Tanaka, A. and S. Funahashi (2012) Macaque monkeys exhibit behavioral signs of metamemory in an oculomotor working memory task. Behavioural Brain Research, 233: 256-270. DOI: 10.1016/j.bbr.2012.05.013.

Watanabe, Y. and Funahashi, S. (2012) Thalamic mediodorsal nucleus and working memory. Neuroscience and Biobehavioral Reviews 36: 134-142. DOI: 10.1016/j.neubiorev.2011.05.003.

Andreau, J.M. and Funahashi, S. (2011) Primate prefrontal neurons encode the association of paired visual stimuli during the pair-association task. Brain and Cognition 76: 58-69. DOI: 10.1016/j.bandc.2011.03.001.

Funahashi, S. (2011) Brain mechanisms of happiness. Psychologia 54: 222-233.

Funahashi, S. and Tanaka, A. (2011) Metacognition: a new method for studying the nature of the mind. In: Brain Science and Kokoro: Asian Perspective on Science and Religion, P. Swanson, ed., pp. 51-67.

Ichihara-Takeda, S., Takeda, K., and Funahashi, S. (2010) Reward acts as a signal to control delay-period activity in delayed-response tasks. NeuroReport 21: 367-370. DOI: 10.1097/WNR.0b013e32833776a3.

Funahashi, S. (2010) Metacognition: a new method to study the nature of the mind. Bulletin of the Nanzan Institute for Religion and Culture　34: 36-40.

Shinomoto, S., Kim, H., Shimokawa, T., Matsuno, N., Funahashi, S., Shima, K., Fujita, I., Tamura, H., Doi, T., Kawano, K., Inaba, N., Fukushima, K., Kurkin, S., Kurata, K., Taira, M. Tsutsui, K., Komatsu, H., Ogawa, T., Koida, K., Tanji, J., and Toyama, K. (2009) Relating neuronal firing patterns to functional differentiation of cerebral cortex. PLoS Computational Biology 5 (7) e10004 33: 1-10. DOI: 10.1371/journal.pcbi.1000433.

Mochizuki, K. and Funahashi, S. (2009) Effect of emotional distracters on cognitive decision-making in Cambridge gambling task. Psychologia 52: 122-136

Takebayashi, M. and Funahashi, S. (2009) Monkeys exhibit preference for biologically non-significant visual stimuli. Psychologia 52: 147-161

Watanabe, Y., Takeda, K., and Funahashi, S. (2009) Population vector analysis of primate mediodorsal thalamic activity during oculomotor delayed-response performance. Cerebral Cortex 19: 1313-1321. DOI: 10.1093/cercor/bhn170.

Funahashi, S. (2008) Learning. In: "The Encyclopedic Reference of Neuroscience" Springer Verlag, (in press)

Ichihara-Takeda, S. and Funahashi, S. (2008) Activity of primate orbitofrontal and dorsolateral prefrontal neurons: effect of reward schedule on task-related activity. Journal of Cognitive Neuroscience, 20: 563-579.

Funahashi, S. (2007) The prefrontal cortex as a model system to understand representation and processing of information. In: "Representation and Brain," S. Funahashi (ed.) Springer Verlag, Tokyo, p. 311-336.

Funahashi, S. (2007) General-purpose working memoru system and functions of the dorsolateral prefrontal cortex. In: "The Cognitive Neuroscience of Working memory: Behavioural and Neural Correlates," N. Osaka, R.H. Logie, & M. D'Esposito (eds.), Oxford University Press, Oxford, p. 213-229.

Watanabe, K. and Funahashi, S. (2007) Prefrontal delay-period activity reflects the decision process of a saccade direction during a free-choice ODR task. Cerebral Cortex, 17: i88-i100.

Ichihara-Takeda, S. and Funahashi, S. (2007) Activity of primate orbitofrontal and dorsolateral prefrontal neurons: Task-related activity during an oculomotor delayed-response task. Experimental Brain Research 181:409-425.

Takeda, K. and Funahashi, S. (2007) Relationship between prefrontal task-related activity and information flow during spatial working memory performances. Cortex 43: 38-52.

Watanabe, K., Igaki, S., and Funahashi, S. (2006) Contributions of prefrontal cue-, delay-, and response-period activity to the decision process of saccade direction in a free-choice ODR task. Neural Networks 19: 1203-1222.

Funahashi, S. (2006) Prefrontal cortex and working memory processes. Neuroscience 139: 251-261.

Ichihara-Takeda, S. and Funahashi, S. (2006) Reward-period activity in primate dorsolateral prefrontal and orbitofrontal neurons is affected by reward schedules. Journal of Cognitive Neuroscience 18: 212-226.

Funahashi, S., Takeda, K., and Watanabe, Y. (2004) Neural mechanisms of spatial working memory: contributions of the dorsolateral prefrontal cortex and the thalamic mediodorsal nucleus. Cognitive, Affective, and Behavioral Neuroscience, 4: 409-420.

Takeda, K. and Funahashi, S. (2004) Population vector analysis of primate prefrontal activity during spatial working memory. Cerebral Cortex 14: 1328-1339.

Watanabe, Y. and Funahashi, S. (2004) Neuronal activity throughout the primate mediodorsal nucleus of the thalamus during oculomotor delayed-responses. I. Cue-, delay-, and response-period activity. Journal of Neurophysiology 92: 1738-1755.

Watanabe, Y. and Funahashi, S. (2004) Neuronal activity throughout the primate mediodorsal nucleus of the thalamus during oculomotor delayed-responses. II. Activity encoding visual versus motor signal. Journal of Neurophysiology 92: 1756-1769.

Funahashi, S. (2004) Book Review: Principles of Frontal Lobe Function. Clinical Neurophysiology 115: 241-242.

Funahashi, S. and Takeda K. (2003) What information is represented by prefrontal neuronal acticvity? In: "Cognition and Emotion in the Brain," T. Ono, G. Matsumoto, R.R. Llinas, A. Berthoz, R. Norgren, H. Nishijo, and R. Tamura (eds.), Excerpta Medica International Congress Series 1250, Elsevier, p. 93-104.

Funahashi, S. (2003) Information processing in the primate prefrontal cortex. In: "Prefrontal Cortex: From Synaptic Plasticity to Cognition," S. Otani (ed.), Kluver Academic Publisher, Boston, p.201-218.

Funahashi, S. (2003) In memoriam: Professor Patricia S. Goldman-Rakic (1937-2003). In: "Prefrontal Cortex: From Synaptic Plasticity to Cognition," S. Otani (ed.), Kluver Academic Publisher, Boston, p.XIII-XIV.

Funahashi, S. and Takeda, K. (2002) Information processes in the primate prefrontal cortex in relation to working memory processes. Reviews in the Neurosciences, 13: 313-346.

Inoue, M. and Funahashi, S. (2002) Prefrontal delay-period activity is affected by visual cues presented outside the memory field. NeuroReport, 13: 2097-2101

Takeda, K. and Funahashi, S. (2002) Prefrontal task-related activity representing visual cue location or saccade direction in spatial working memory tasks. Journal of Neurophysiology , 87: 567-588

Funahashi, S. and Takeda, K. (2002) Population-vector analysis by primate prefrontal neuron activities. Journal of Biological Physics, 28: 1-11

Funahashi, S. (2001) Neuronal mechanisms of executive control by the prefrontal cortex. Neuroscience Research, 39: 147-165.

Funahashi, S. and Inoue, M. (2000) Neuronal interactions related to working memory processes in the primate prefrontal cortex revealed by cross-correlation analysis. Cerebral Cortex, 10: 535-551.

Sakai, Y., Funahashi, S., and Shinomoto, S. (1999) Temporally correlated inputs to leaky integrate-and-fire models can reproduce spiking statistics of cortical neurons. Neural Networks, 12: 1181-1190.

Shinomoto, S., Sakai, Y., and Funahashi, S. (1999) The Ornstein-Uhlenbeck process does not reproduce spiking statistics of neurons in prefrontal cortex. Neural Computation 11: 935-951.

Funahashi, S., Inoue, M., and Kubota, K. (1997) Delay-period activity in the primate prefrontal cortex encoding multiple spatial positions and their order of presentation. Behavioral Brain Research　84: 203-223.

Funahashi, S.(1996) Prefrontal cortex and working memory. In: Brain Processes and Memory. K. Ishikawa, J.L. McGaugh, and H. Sakata (eds.) Excerpta Medica International Congress Series 1108: 397-410.

Funahashi, S. and Kubota, K. (1994) Working memory and prefrontal cortex. Neuroscience Research, 21: 1-11.

Funahashi, S., Inoue, M., and Kubota, K. (1993) Delay-related activity in the primate prefrontal cortex during sequential reaching tasks with delay. Neuroscience Research, 18: 171-175.

Funahashi, S., Bruce, C.J., and Goldman-Rakic, P.S. (1993) Dorsolateral prefrontal lesions and oculomotor delayed-response performance: evidence for mnemonic scotomas. Journal of Neuroscience, 13: 1479-1497.

Funahashi, S., Bruce, C.J., and Goldman-Rakic, P.S. (1993) Saccade-related activity in the primate prefrontal cortex and its role in working memory processes. Biomedical Research, 14 (Suppl. 1): 85-88.